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Boundary element method for optical force calibration in microfluidic dual-beam optical trap

机译：微流双光束光阱中光力校准的边界元方法

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The potential use of optical forces in microfluidic environment enables highly selective bio-particle manipulation. Manipulation could be accomplished via trapping or pushing a particle due to optical field. Empirical determination of optical force is often needed to ensure efficient operation of manipulation. The external force applied to a trapped particle in a microfluidic channel is a combination of optical and drag forces. The optical force can be found by measuring the particle velocity for a certain laser power level and a multiplicative correction factor is applied for the proximity of the particle to the channel surface. This method is not accurate especially for small microfluidic geometries where the particle size is in Mie regime and is comparable to channel cross section. In this work, we propose to use Boundary Element Method (BEM) to simulate fluid flow within the micro-channel with the presence of the particle to predict drag force. Pushing experiments were performed in a dual-beam optical trap and particlea's position information was extracted. The drag force acting on the particle was then obtained using BEM and other analytical expressions, and was compared to the calculated optical force. BEM was able to predict the behavior of the optical force due to the inclusion of all the channel walls. © 2015 SPIE.
机译：在微流体环境中光力的潜在使用实现了高度选择性的生物粒子操纵。可以通过捕获或推动由于光场引起的粒子来完成操纵。通常需要根据经验确定屈光力，以确保有效的操纵操作。施加到微流体通道中捕获粒子的外力是光学力和阻力的组合。可以通过测量一定激光功率水平下的粒子速度来找到光学力，并对粒子与通道表面的接近程度应用乘以校正因子。该方法尤其对于颗粒尺寸处于Mie范围且可与通道横截面相当的微流体小几何结构尤其不准确。在这项工作中，我们建议使用边界元方法（BEM）来模拟存在微粒的微通道内的流体流动，以预测阻力。在双光束光阱中进行推挤实验，并提取粒子的位置信息。然后使用BEM和其他分析表达式获得作用在颗粒上的阻力，并将其与计算出的光学力进行比较。由于包含所有通道壁，BEM能够预测光学力的行为。 ©2015 SPIE。

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